Frank died peacefully from Parkinson’s Disease on Sunday, August 18 at Strong Memorial Hospital. He is survived by his wife of 41 years, Kim Hober; sons, Philip (Kaylynn Enright) Gigliotti and Nicholas Gigliotti; siblings, Kathy (Brent) Gigliotti Nelson, Carmen (Brendan) Gigliotti Taylor, and Dr. O. Steven (Loren Goldkorn) Gigliotti and several nieces and nephews.

Frank was born in Cumberland, Maryland. He was a graduate of West Virginia University and attended medical school and residency at the University of Virginia. He completed his fellowship in Pediatric Infectious Disease at the University of Rochester. He joined the faculty at St. Jude Children’s Research Hospital in 1983 and returned to the University of Rochester in 1988 to join the Department of Pediatrics. Frank held a joint appointment in the Department of Microbiology and Immunology. He served as chief of Pediatric Infectious Disease for 27 years. He also served as Associate Director of Strong Children’s Research Center and Associate Chair for Academic Affairs for the Department of Pediatrics. He was the Lindsey Distinguished Professor for Pediatrics and was appointed Professor Emeritus of Pediatrics on April 18, 2024.

Frank was a nationally distinguished physician/scientist and directed research in his National Institutes of Health-funded laboratory for 33 years. He was a renowned member of several national and international medical and scientific associations and was recruited to serve on a number of NIH Research Study Sections. Over the span of his career Frank contributed several seminal research discoveries that not only advanced the basic understanding of infectious disease, but also reshaped the clinical approach to treating patients. He was passionate about advancing the treatment of disease in those with compromised immune systems, with his life work devoted to advancing our understanding of the pathogenesis and treatment of Pneumocystis pneumonia, a disease that leads to severe morbidity and mortality in those with immunodeficiency.

Frank oversaw the Pediatric Infectious Disease Fellowship Program and during his long career trained many young physicians and scientists. He was devoted to medical teaching and mentorship and was awarded several teaching awards during his tenure. Students he mentored now have built their own successful research programs both in the United States and beyond.

A wine enthusiast and fan of Finger Lakes wines, Frank spent many vacations and weekends traveling through the region. He was an expert cook and gardener and always looked forward to that first tomato of the summer. He coached Little League and North Coast baseball when his sons were young, and he was an avid fan of the Buffalo Bills and the New York Yankees. However, he mostly enjoyed sitting on his patio or in front of a fire, enjoying a glass of wine, and spending time with his friends and family.