The John Vowles House was built in 1824 by James Densmore, master craftsman for Thomas Jefferson. It is thought to be the oldest building on West Main Street and is listed on the National Register of Historic Places.

The University of Virginia Medical Alumni Association, established in 1949, is an independent organization of more than 12,000 members dedicated to service for the benefit of the School of Medicine and the University of Virginia.  Its Board of Directors governs the Medical Alumni Association.

The University of Virginia Medical School Foundation, established in 1972, exists as the financial arm of the University of Virginia Medical Alumni Association.  Its mission is to receive, invest, manage and disburse funds for the express purpose of maintaining and constantly improving the state of excellence of the University of Virginia School of Medicine. The Trustees and Officers promote a climate that empowers those with whom we serve, while stewarding our human and financial resources.

The UVA Medical Alumni Association and Medical School Foundation operates as an independent 501(C)(3) organization.

With headquarters located at 1111 West Main Street and a small, full-time staff, the association sponsors more than 50 annual programs and events for students, alumni, and housestaff.  Some of the most popular events include Medical School Reunion Weekend, the White Coat Ceremony, Money Talks financial lectures, LegacyConnect and Family Day.  In addition, the association publishes the University of Virginia School of Medicine Vitals magazine, the Capsule bi-monthly e-newsletter, and annual alumni directories for reunion classes. Special student services include an emergency loan program, scholarship assistance, the Host program, the UVA MedConnect mentoring program, and Global Health Travel Awards.